Dr. James Lee

Research Mission:

Associate Professor of Bioengineering

NIH Posdoctoral Fellow. Lawrence Berkeley National Laboratory (2001)

Ph.D. Chemical Engineering. University of Pennsylvania.(2000)

B.S. Chemical Engineering. University of California, Berkeley.(1996)

Alzheimer's Association New Investigator (2007)

The mission of our research group is to apply biophysical engineering principles and techniques to investigate the mechanochemical processes in neurodegenerative diseases, especially Alzheimer’s disease (AD). Specifically, we focus on the roles of mechanical properties (nN to pN scale), molecular packing and molecular organization (~nm) of membranes, cytoskeleton and their components in altered cell functions in AD, including astrogliosis, amyloid precursor protein processing, cerebral endothelial dysfunction, clearance of amyloid beta peptide, and neurogenesis. Various nano-mechanical characterizations, modern fluorescence microscopic and spectroscopic, and photonic techniques, and cell manipulation techniques, including atomic force microscopy, micropipette cell manipulation and aspiration, quantitative fluorescent confocal microscopy, beam splitter, and laser are employed in both basic biomedical and clinical research projects. Ultimately, the information derived from our research will provide insights into the mechanisms underlying the pathology of the disease, early diagnosis, and therapeutic strategies. Our research has been funded by NIH and Alzheimer Association.

Ph.D. Students

Xue Geng, Illinois Institute of Technology

Tao Teng, University of Missouri

Stephanie Tolbert, University of Michigan

M.S. Students

Cecilia Brambilla Pisoni, Politecnico Di Milano

Chia Hung Yen, Kaohsiung Medical University